ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF POORLY WATER SOLUBLE CLARITHROMYCIN USING MICROWAVE INDUCED FUSION METHOD
Author(s):
SHITAL A. KASTURE, Nilesh R. Bhosale , Dr. Rajashree Chavan, Ankita V. Bhosale
Keywords:
Clarithromycin, Solid Dispersion, Microwave- Induced Fusion Method, Solubility Enhancement.
Abstract
The objective of the present work was to enhance the solubility and dissolution rate of the drug Clarithromycin, which is poorly soluble in water. Comparing the solubility of HPMC and PVP and HPMC show better result than PVP. The solubility of Clarithromycin was observed to increase with increasing concentration of hydroxypropyl methylcellulose. The optimized ratio for preparing a solid dispersion (SD) of RLX with HPMC using the microwave-induced fusion method. Microwave energy was used to prepare SDs. HPMC was used as a hydrophilic carrier to enhance the solubility and dissolution rate of Clarithromycin. After microwave treatment, the drug and hydrophilic polymer are fused together, and the drug is converted from the crystalline form into an amorphous form. This was confirmed through scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and UV studies. These results suggested that the microwave method is a simple and efficient method of preparing SDs and solubility was found that 1:5 w/w. The solubility and dissolution rate of the SDs were increased significantly compared with pure Clarithromycin due to the surfactant and wetting properties of HPMC and the formation of molecular dispersions of the drug in HPMC. Conclusion-It was concluded that the solubility and dissolution rate of Clarithromycin are increased significantly when an SD of the drug is prepared using the microwave-induced fusion method.
Article Details
Unique Paper ID: 160427

Publication Volume & Issue: Volume 10, Issue 1

Page(s): 811 - 815
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