A NOVEL APPROACH TO DEVELOP TRAMADOL HYDROCHLORIDE TRANSDERMAL FILMS WITH COMPLETE IN-VITRO EVALUATION

A NOVEL APPROACH TO DEVELOP TRAMADOL HYDROCHLORIDE TRANSDERMAL FILMS WITH COMPLETE IN-VITRO EVALUATION
Author(s):
Kabita Banik, Dr. Namratha, Ms. Twila, K Harika
Keywords:
Transdermal films, Hydroxypropyl methyl cellulose, Ethylcellulose polymer, Tramadol HCl
Abstract
The oral route is now the most prevalent method of medication administration. While it has the benefit of being simple to administer, it also has substantial disadvantages, including low bioavailability due to hepatic metabolism and the propensity to cause fast blood level spikes, necessitating high and/or frequent doses, which may be expensive and inconvenient. In this study, hydroxypropyl methyl cellulose 6 cps (HPMC 6 cps) and ethyl cellulose are used as release-controlling polymers to create a matrix type transdermal drug delivery system for the analgesic medication tramadol HCl for its systemic delivery.This new drug delivery systems has increased the therapeutic efficacy and safety of pharmaceuticals by allowing for more accurate, site-specific delivery system, it allows temporal placement inside the body, resulting in smaller dosages consumption.
Article Details
Unique Paper ID: 160945 Publication Volume & Issue: Volume 10, Issue 2 Page(s): 160 - 166
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