SYNTHESIS OF INNOVATIVE ISOXAZOLIDINES Via 1, 3 - DIPOLAR CYCLOADDITION OF α -FURFURAL-ARYL-N-ARYL-NITRONE WITH CINNAMALDEHYDE AND ITS ANTIBACTERIAL ACTIVITIES
Author(s):
SIVADHARANI P, JAYAPRADHA S R
Keywords:
1,3 dipole, nitrones, 1,3 dipolar cycloaddition, dipolarophile, antibacterial activity.
Abstract
Cycloaddition is a significant pathway among numerous economical chemical processes due to its stereospecificity, capacity to produce complex compounds, and atom economy. The most common method for synthesizing the isoxazolidine ring system is 1,3-dipolar cycloaddition among nitrones and substituted alkenes, comprising electron-rich and electron-poor dipolarophiles. Nitrone is a prevalent dipole in the 1,3-dipolar cycloaddition process because it is persistent and does not need in vitro development. The 1,3-dipolar cycloaddition of nitrones with different dipolarophiles generates various heterocyclic rings. Because nitrones are simple derivatives of carbonyl compounds, the reaction sequence from carbonyl compounds (mostly aldehydes) to nitrone synthesis of the five-membered ring system and subsequent breakdown of the cycloadduct provides a route to new carbonyl compounds called isoxazolidines. This article focuses on nitrones that perform cycloaddition with diverse sources to produce heterocyclic rings. Using spectroscopic techniques, the structures of the generated compounds were identified.
Article Details
Unique Paper ID: 161531

Publication Volume & Issue: Volume 10, Issue 4

Page(s): 489 - 494
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