K. Satish Kumar, Dr. K.Srikanth
Bilayer tablets, API, Formulation, Controlled release, frequency of dosing,, Floating drug delivery system, Release Pattern, Characterization and In-vivo success of GRDDS.
Over a past few decades, around 90% drugs have been formulated for the purpose of oral delivery. Oral ingestion is the most convenient and commonly employed route of drug delivery, due to its ease of administration, high patient compliance, cost effectiveness, least sterility constraints, and flexibility in the design of dosage form. Due to these properties oral dosage form has gained much attention and became the popular class of formulation worldwide. Bilayer tablets do offer a definite advantage over conventional release formulations of the same drug. So as to overcome the problems associated with the conventional dosage form, there arose an interest in developing the controlled drug delivery system in the form of bilayer tablets. Now a day the use of bilayer tablets has been increased in the pharmaceutical industry. Bilayer tablet technology is a new emerging era, in the pharmaceutical industry. Bilayer tablet is the novel technology for the development of controlled release formulation and developing a combination of two or more active pharmaceutical (API) ingredients in a single dosage form. Bilayer tablet technology can be a crucial role for development of controlled release in order to give a successful drug delivery and can be a primary option to avoid chemical incompatibilities between API by physical separation, and to enable the development of different drug release profiles (Immediate and Controlled Release in Single Tablet). Drugs which are formulated in the form of biphasic system have different biological applications such as analgesic, antipyretic, antiallergenic, coronary vasodilators, antihypertensive and anti-histaminic. Oral route of administration involve oral controlled drug delivery which aims to deliver drug for an extended period of time which provide good bioavailability and makes the dosage form reproducible. The system gets many difficulties due to physiological problems like absorption window is narrow for some drugs and alteration in emptying time of stomach and drugs has stability issues in intestine. To overcome these difficulties GRDDS is designed which provide oral controlled sustained dosage form as it delivers the drug at slow rate in systemic circulation and maintains effec
Article Details
Unique Paper ID: 162070

Publication Volume & Issue: Volume 10, Issue 7

Page(s): 378 - 386
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