Evaluation of Extended High-frequency hearing in individuals consuming PDE5i drugs
Author(s):
Chandrahas Chandanshive, R. Rangasayee
Keywords:
Hearing, Extended High-frequency audiometry, PDE5i.
Abstract
Introduction: The cellular degeneration of inner ear post consumption of a drug is called as ototoxicity. The drugs like phosphodiesterase type 5 inhibitors (PDE5i) are widely used as vasodilators. These drugs are found to have been studied widely as therapeutic agents in treating cardiac ailments, hypertension, and erectile dysfunction. A few case studies and case series have attempted to explore the effect of these drugs on hearing. However, there is a dearth of literature documenting the hearing sensitivity of individuals consuming PDE5i drugs. The current study is an attempt to document the extended high-frequency hearing of patients consuming the drugs. Patients and methods: The participants were recruited using the purposive sampling technique. Eighty participants in the observation group were diagnosed with erectile dysfunction. Forty-five typical individuals were recruited in the control group. Following the routine hearing evaluation comprising of pure-tone audiometry and Immittance Audiometry, extended high-frequency audiometry was performed and the data thus obtained was subjected to statistical analysis. Result: It was observed that the hearing sensitivity of the participants was significantly poorer at 14000Hz and 16000Hz frequencies. However, the hearing and middle ear status was within normal limits for the routine pure-tone audiometry and immittance audiometry. Conclusion: There is a significant reduction in extended high-frequency hearing in individuals consuming phosphodiesterase type 5 inhibitors (PDE5i).
Article Details
Unique Paper ID: 162232

Publication Volume & Issue: Volume 10, Issue 8

Page(s): 492 - 496
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