Review on Sodium Valproate: Mechanism, Pharmacokinetics, Adverse Effects

Review on Sodium Valproate: Mechanism, Pharmacokinetics, Adverse Effects
Author(s):
Chakshu Walia, Deepali Thakur, Parul Verma
Keywords:
fetal, valproate, Pharmacokinetics, toxicity
Abstract
Valproate (valproic acid, VPA, sodium valproate, and valproate semi sodium forms) are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. They are useful for the prevention of seizures in those with absence seizures, partial seizures, and generalized seizures. They can be given intravenously or by mouth, and the tablet forms exist in both long- and short-acting formulations. Valproate's precise mechanism of action is unclear. Proposed mechanisms include affecting GABA levels, blocking voltage-gated sodium channels, inhibiting histone deacetylases, and increasing LEF1. Valproic acid is a branched short-chain fatty acid (SCFA), a derivative of valeric acid.
Article Details
Unique Paper ID: 162812 Publication Volume & Issue: Volume 10, Issue 11 Page(s): 81 - 88
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