Review on Dose, Destination and Delivery aspects of Methotrexate
Author(s):
Chakshu Walia, Naveen Sharma, Nitish Kumar, Deepali Thakur
Keywords:
Inflammation, Methotrexate, immune system, Mechanism, dose, adverse effects.
Abstract
Methotrexate drug belongs to the group of medicines i.e., Antineoplastics (cancer medicines). It leads in blockage of enzyme that is needed by cells to live. It is also used to treat certain types of cancer (such as acute lymphoblastic leukemia, non-Hodgkin's lymphoma) or to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. It is also used to reduce the activity of the immune system for people who are suffering from such problems. The immune system normally protects the body from infections by cause’s inflammation to fight against them. There are several sign and symptoms of inflammation i.e., redness, swelling, heat and pain. MTX is now prescribed atleast 500,000 patients with RA worldwide, making it far the most commonly used disease modifying antirheumatic drug. It has been used to treat millions of patients with malignant and autoimmune diseases. Methotrexate has been used clinically in the treatment of malignancy, psoriasis, rheumatoid arthritis, and other autoimmune and inflammatory disorders. Methotrexate has also been used with misoprostol for voluntary abortion and in the treatment of ectopic pregnancy
Article Details
Unique Paper ID: 162705

Publication Volume & Issue: Volume 10, Issue 10

Page(s): 792 - 800
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