Development and Impact of Pathogen on Toxemia

Ankush Pal

Development and Impact of Pathogen on Toxemia

Authors: Ankush Pal

Unique Paper ID: 162997
Volume: 7
Issue: 11
PageNo: 772-776

Keywords: sepsis; bacteria; virus; COVID-19; immunity

Abstract:
Sepsis, a severe global healthcare challenge, is characterized by significant morbidity and mortality. The 2016 redefinition by the Third International Consensus Definitions Task Force emphasizes its complexity as a â€œlife-threatening organ dysfunction caused by a dysregulated host response to infectionâ€. Bacterial pathogens, historically dominant, exhibit geographic variations, influencing healthcare strategies. The intricate dynamics of bacterial immunity involve recognizing pathogen-associated molecular patterns, triggering innate immune responses and inflammatory cascades. Dysregulation leads to immunothrombosis, disseminated intravascular coagulation, and mitochondrial dysfunction, contributing to the septic state. Viral sepsis, historically less prevalent, saw a paradigm shift during the COVID-19 pandemic, underscoring the need to understand the immunological response. Retinoic acid-inducible gene I-like receptors and Toll-like receptors play pivotal roles, and the cytokine storm in COVID-19 differs from bacterial sepsis. Latent viruses like human cytomegalovirus impact sepsis by reactivating during the immunosuppressive phases. Challenges in sepsis management include rapid pathogen identification, antibiotic resistance monitoring, and balancing therapy beyond antibiotics. This review highlights the evolving sepsis landscape, emphasizing the need for pathogen-specific therapeutic developments in a dynamic and heterogeneous clinical setting.

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Cite This Article

ISSN: 2349-6002
Volume: 7
Issue: 11
PageNo: 772-776

Development and Impact of Pathogen on Toxemia

Available:https://ijirt.org/Article?manuscript=162997

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Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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