Formulation and evaluation of mucoadhesive tablet of Ranolizine
Author(s):
Shyamsundar Babanrao Sakhre, Pritam Salokhe, Nilesh Chougule
Keywords:
Hardness, friability, thickness, weight uniformity, drug content, drug release, swelling study, in-vitro drug release and in-vitro mucoadhesive strength.
Abstract
Ranolazine, a promising drug for the management of chronic angina, poses challenges in achieving sustained release and localizing its effect at the target site due to its short half-life and frequent dosing regimen. This study aimed to develop mucoadhesive tablets of ranolazine to enhance its bioavailability, prolong its release, and improve patient compliance. The tablets were formulated using various polymers, including hydroxypropyl methylcellulose (HPMC), Carbopol, and sodium alginate, to achieve the desired mucoadhesive properties. The formulations were characterized for drug content, swelling index, mucoadhesive strength, in vitro drug release, and ex vivo mucoadhesion time. The optimized formulation exhibited satisfactory characteristics, with prolonged drug release over 12 hours, strong mucoadhesive properties, and enhanced bioavailability. In conclusion, mucoadhesive tablets of ranolazine hold promise as a potential dosage form for improving therapeutic outcomes and patient adherence in the treatment of chronic angina.
Article Details
Unique Paper ID: 165853

Publication Volume & Issue: Volume 11, Issue 1

Page(s): 1876 - 1884
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