Phytochemical and Pharmacological Activity of Insulin Plant
Author(s):
Prathamesh Ramesh Dongare, N.B.Chougule
Keywords:
Ethnopharmacology, diabetes, medicinal plants, diabetes mellitus, anti-diabetics, hyperglycemia.
Abstract
Medicinal plant usage is becoming more common in developing nations like South Africa to treat diabetes mellitus. The claims made by traditional healers are being backed by more and more scientific evidence. We rank the anti-diabetic activity and mode of action of the families of previously documented anti- diabetic plants in the Eastern Cape and highlight their therapeutic potentials based on the available data on their pharmacology and toxicity. A thorough literature search of the 45 plants mentioned in ethnobotanical surveys was conducted using the keywords "plant name" and "family" for the primary searches in the electronic databases PubMed, ScienceDirect, Google Scholar, and Elsevier. This helped identify the plants that have been the subject of scientific investigations for their potential to prevent diabetes. After 25 families were found, the most highly reported were Asteraceae, then Asphodelaceae and Alliaceae. A significant number of plants have been investigated for their potential to prevent diabetes, both in vivo and in vitro. The majority of these plants exhibit a greater percentage of insulin release and inhibition of enzymes that break down carbohydrates when compared to insulin mimetic and peripheral glucose uptake. As part of their hypoglycemic action with reduced toxicity, nearly all of the plants under investigation also inhibit oxidative stress. Still lacking, though, is the isolation of their bioactive molecules. This review offers a tool to facilitate comprehensive evaluations of the therapeutic profiles of medicinal plants that are currently available and used in the Eastern Cape, South Africa, to treat diabetes. In order to find new molecules for drug development and discovery, more research is necessary. One such study that needs to be done is identifying the active ingredients of powerful plants. Diabetes mellitus is a collective term for a range of metabolic diseases that affect a large portion of the global population. The primary feature is persistent hyperglycemia, which is caused by deficiencies in either insulin secretion or insulin action.
Article Details
Unique Paper ID: 166175

Publication Volume & Issue: Volume 11, Issue 2

Page(s): 180 - 186
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