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RECENT TRENDS IN INSULIN DELIVERY BY MEANS OF TECHNOSPHERE DRUG DELIVERY MECHANISM: A REVIEW

  • Unique Paper ID: 166595
  • Volume: 11
  • Issue: 2
  • PageNo: 1293-1301
  • Abstract:
  • Technosphere/Insulin [TI] is formulation of regular human insulin designed for efficient transport across respiratory epithelium into the circulation. The drug carrier mechanism achieves a fast systemic insulin uptake (maximum time 15-20 min.), a fast onset of action (maximum activity 25-30 min.) and short duration of action (2 h). Bioavailability relative to subcutaneous injection was established to be between 30 and 50% with a linear dose response relationship and low variability. In all published short-term study, TI was well tolerated. Provided a reliable long term safety profile, TI may become a suitable alternative to subcutaneous injection for prandial insulin delivery. TI offers the possibility of new treatment regimens, especially in patient with type 2 diabetes.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 2
  • PageNo: 1293-1301

RECENT TRENDS IN INSULIN DELIVERY BY MEANS OF TECHNOSPHERE DRUG DELIVERY MECHANISM: A REVIEW

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