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@article{166808,
        author = {Mr. Shaikh Suleman A.R. and Dr. Rana Zainuddin Ahmed and Dr. M.H. Dehghan and Dr. Kazi Marzuka},
        title = {Ophthalmic Liquid Crystal In-Situ Gel Formulation and Evaluation -Insight from a Systematic Literature Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {2},
        pages = {2013-2017},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=166808},
        abstract = {The formulation and evaluation of ophthalmic liquid crystal in situ-gels have gained significant interest in recent years for their potential as advanced drug delivery systems in ophthalmology. This review article aims to provide an overview of the formulation strategies and evaluation methods used for ophthalmic liquid crystal in situ-gels, highlighting their advantages, challenges, and potential applications in ocular drug delivery. The in situ-gel undergoes a sol-gel transition upon contact with the ocular surface, providing sustained release and improved bioavailability. The evaluation includes the assessment of its physical characteristics, in vitro release profile, bioadhesive properties, stability, compatibility, and ocular irritation potential. Liquid crystal is a key component used in the development of ophthalmic in situ gels. Liquid crystals exhibit properties of both liquids and solids, making them ideal for drug delivery in this formulation. They have a unique ability to self-assemble into ordered structures, which can help in prolonging drug release.},
        keywords = {Ophthalmic, In-Situ Gel, Liquid Crystals, Ocular Drug Delivery},
        month = {July},
        }