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Development of validated Spectrophotometric Methods: Simultaneous Equation Method and Q-Absorption Ratio method and for Simultaneous Estimation of Secnidazole and Ciprofloxacin.

  • Unique Paper ID: 166970
  • Volume: 4
  • Issue: 5
  • PageNo: 282-290
  • Abstract:
  • Two simple, accurate, sensitive and economical spectrophotometric methods have been developed and subsequently validated for determination of Ciprofloxacin and Secnidazole in bulk. For the simultaneous equation method, the estimation of Secnidazole and Ciprofloxacin was carried out at 319 nm (λ max of Secnidazole) and 271.2 nm (λ max of Ciprofloxacin). For Q - absorption ratio method, estimation of Secnidazole and Ciprofloxacin at 282 was carried out at 319 nm (λ max of Secnidazole) and 282 nm (isosbestic point of both drugs). Calibration curves of Secnidazole and Ciprofloxacin were found to be linear in the concentration ranges of 1-25 𝜇g/mL, with their correlation coefficient values (r2) being more than 0.995. In the precision study, the % RSD value was found within limits (RSD < 2%). The percentage recovery for Secnidazole at various concentration levels varied from 100.14 to 102.14 % and 1.1.2 to 102.13 by Method I and II respectively, While The percentage recovery for Ciprofloxacin varied from 100.52 to 101.51 and 100.3 to 101.33 by Method I and II respectively confirming that the projected methods are termed as an accurate and it can be applied successfully for the simultaneous estimation of Secnidazole and Ciprofloxacin in pure combined form.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 4
  • Issue: 5
  • PageNo: 282-290

Development of validated Spectrophotometric Methods: Simultaneous Equation Method and Q-Absorption Ratio method and for Simultaneous Estimation of Secnidazole and Ciprofloxacin.

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