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@article{167896,
        author = {Rohit Chettri and Prem Kumar N and Sushil Gurung and Sairashmi Samanta and Royan Chhetri and Ankit Kumar Mahato and Samuel chettri and Prodeep Das},
        title = {A Phytoconstituent-MicroRNA Axis: Unveiling Therapeutic Potential in Insulin Resistance},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {4},
        pages = {835-845},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=167896},
        abstract = {Diabetes mellitus (DM) remains a leading cause of global morbidity and mortality, with insulin resistance (IR) serving as a key underlying factor in its pathogenesis. IR, characterized by the diminished responsiveness of insulin-sensitive tissues, is a critical precursor to a spectrum of metabolic disorders, including type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases. Recent research has underscored the pivotal role of microRNAs (miRNAs), small endogenous noncoding RNAs, in the regulation of mRNA stability and translation, thereby influencing the development and progression of IR and T2DM. Concurrently, phytochemicals—bioactive compounds derived from plants—have gained attention for their therapeutic potential, particularly due to their antioxidant, anti-inflammatory, and pharmacological properties. These natural compounds have been shown to modulate miRNA expression, regulate gut microbiota, and exert immunomodulatory effects, offering promising avenues for the prevention and management of IR and its miRNA complications. This review delves into the specific interactions between phytochemicals and miRNA profiles, exploring how these interactions can mitigate IR and reduce the risks associated. Furthermore, the review highlights the potential of miRNA as novel biomarkers for early diagnosis and prevention of IR, suggesting their integration into therapeutic strategies aimed at combating the global burden of diabetes. Through this exploration, the article aims to illuminate new pathways for the management and mitigation of IR, contributing to the advancement of diabetes care and the reduction of associated health risks.},
        keywords = {Insulin Resistance, miRNA, Phytochemicals},
        month = {September},
        }