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Preparation and Evaluation of Eberconazole Nitrate Nanoemulgel For Treatment of Fungal Infections

  • Unique Paper ID: 169289
  • Volume: 11
  • Issue: 6
  • PageNo: 1191-1195
  • Abstract:
  • The objective of this study was to develop a nanoemulgel that would facilitate the topical administration of the antifungal drug eberconazole, which is beneficial in the treatment of fungal infections. Cabopol 934 gelling agent, Almond Oil, Polysorbate 80, Propylene glycol were employed in the eberconazole Nanoemulgel formulation. Diverse parameters were examined in the nanoemulgel that had been prepared. The physical appearance, viscosity, drug release, globule size, scanning electron microscopy, and stability of the nanoemulgel that was prepared were assessed. The formulation F7 exhibited the highest activity, as evidenced by the drug release of 96.16 at 24 hours through a diffusion-controlled mechanism. Comparative analysis of Optimized formulation F7 and Marketed formulation (Ebernet) investigated and revealed that the drug was released at a higher rate from the enhanced (F7) emulgel formulation than the commercial gel. The gel contains 0.1% concentration. With a release rate of 96%, the perfected formulation shows regulated drug release for up to 24 hours. By contrast, the marketed formulation shows drug release of 92% for up to 12 hours. Consistent release over a 24-hour period shown by Formulation F7 suggests enhanced contact with the cellular membrane.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 6
  • PageNo: 1191-1195

Preparation and Evaluation of Eberconazole Nitrate Nanoemulgel For Treatment of Fungal Infections

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