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Effect of Polymers and Gas Forming Agents on the Floating Tablets of Acyclovir & Zidovudine

  • Unique Paper ID: 168219
  • Volume: 11
  • Issue: 5
  • PageNo: 134-141
  • Abstract:
  • Acyclovir, a commonly prescribed antiviral medication for the treatment of HIV/AIDS, and Zidovudine prevent HIV from replicating in human cells. Because of this, they are nearly insoluble in water and other aqueous fluids, which presents difficult formulation and development issues. The goal of this work was to build and optimize Acyclovir floating drug delivery systems employing sodium bicarbonate as a gas-generating agent and xanthan gum as the polymer. Zidovudine tablets were made with various ratios of microcrystalline cellulose, magnesium state, talc, sodium bicarbonate, citric acid, lactose, carbopol 934, and HPMC K4M and K15M utilizing PVP K30. In the presence of the dissolution medium (0.1 N HCl), sodium bicarbonate was introduced as a gas producing agent, causing carbon dioxide to be produced. Citric acid and sodium bicarbonate together gave the required floating ability, hence this combination was chosen for the formulation. Hardness, friability, weight variation, homogeneity of drug content, swelling index, in vitro buoyancy, and in vitro drug release profile were assessed for every intended batch of formulations. Every formulation floated continuously on the dissolution medium for over 24 hours, with a floating lag time of one to three minutes. The acquired data showed that all formulations showed a dissolving behavior regulated by non-Fickain diffusion, and that drug release occurred via mixed order kinetics. These investigations indicate that the formulation offers regulated release of the medication and is kept in the stomach for extended lengths of time. Consequently, enhance the drug's therapeutic impact by raising its bioavailability. The current study comes to the conclusion that the formulation ZF2, which contains 100 mg of HPMC K4M and AF4 containing 150 mg of Xanthan gum had the maximum drug release in the shortest amount of time.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 5
  • PageNo: 134-141

Effect of Polymers and Gas Forming Agents on the Floating Tablets of Acyclovir & Zidovudine

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