Self-Emulsifying Drug Delivery Systems; An Overview

Mr.Sujeetkumar I.Ahire; Mrs.Sandhya S.Ahire; Miss.Akshata A.Jain; Miss.Yugandhara R.Mahajan; Mr.Makrand R.Patil

Self-Emulsifying Drug Delivery Systems; An Overview

Authors: Mr.Sujeetkumar I.Ahire, Mrs.Sandhya S.Ahire, Miss.Akshata A.Jain, Miss.Yugandhara R.Mahajan, Mr.Makrand R.Patil

Unique Paper ID: 170741
Volume: 11
Issue: 7
PageNo: 1645-1649

Keywords: SEDDS nanoemulsions precipitation inhibitors surfactants.

Abstract:
The primary goal of research on self-emulsifying drug delivery systems (SEDDS) has been to increase the oral bioavailability of medications that fall under class II of the Biopharmaceutics Classification System. Self-emulsifying drug delivery systems (SEDDS) have the potential to significantly increase the oral bioavailability of medications that are not highly soluble in water. These systems quickly dissolve in gastrointestinal fluids after oral delivery, producing micro or nanoemulsions that contain the solubilized medication.Medium chain tri-glyceride oils and non-ionic surfactants—the latter of which is less toxic—have recently been used in the formulation of SEDDS. Since the addition of precipitation inhibitors (PIs) to SEDDSs aids in maintaining drug super saturation following dispersion and digestion in the gastrointestinal tract, supersaturable SEDDSs, or su-SEDDSs, have drawn attention as a means of overcoming these restrictions that limit the potential use of such systems. A pre-concentrate made up of a medication, oils, surfactants, and occasionally co-solvents and/or co-surfactants is called a SEDDS. Additionally, we summarize various solidification techniques employed to transform liquid SEDDS to the more stable solid self-emulsifying drug delivery systems (s-SEDDS) that are associated with high patient compliance.

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Cite This Article

ISSN: 2349-6002
Volume: 11
Issue: 7
PageNo: 1645-1649

Self-Emulsifying Drug Delivery Systems; An Overview

Available:https://ijirt.org/Article?manuscript=170741

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UGC Approved
Journal no 47859

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