Author Login IJIRT Partner Network (IPN) Login

Emerging Trends in Bioactive Molecule Synthesis: A Focus on Cycloaddition and Click Reactions for Anticancer Applications

  • Unique Paper ID: 171979
  • Volume: 11
  • Issue: 8
  • PageNo: 1597-1609
  • Abstract:
  • The creation of bioactive compounds, notably anticancer drugs, has advanced dramatically thanks to novel synthetic techniques. Among these, 1,3-dipolar cycloaddition and click chemical processes have emerged as powerful tools in current medicinal chemistry. These reactions provide outstanding accuracy, efficiency, and adaptability in the construction of complex molecular frameworks with a wide range of functionalities. 1,3-Dipolar cycloaddition allows to produce of five-membered heterocyclic compounds, which are important scaffolds in many medicinal chemicals. Because of its regioselectivity and wide substrate range, this reaction is ideal for the development of anticancer drugs. Similarly, click chemistry, particularly copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), has proven critical in developing molecular entities with specific biological functions. Its simplicity, biocompatibility, and resilience make it ideal for drug discovery applications. This study investigates the convergence of these methods, focusing on their use in synthesizing new chemical entities (NCEs) with powerful anticancer effects. It highlights current developments in reaction optimization, catalyst development, and green chemistry methods to improve sustainability. Furthermore, case examples of effective anticancer drugs synthesized using these reactions are investigated, indicating their efficiency in targeting cancer pathways while minimizing off-target effects.The combined use of cycloaddition and click chemistry in cancer research represents a paradigm change toward more efficient and tailored drug development. By combining standard synthetic methods with creative reaction design, these technologies have the potential to create next-generation anticancer medicines. This study seeks to give a thorough knowledge of these interactions, therefore encouraging future research into more sustainable and successful cancer therapies.
Download article email to a friend

Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 8
  • PageNo: 1597-1609

Emerging Trends in Bioactive Molecule Synthesis: A Focus on Cycloaddition and Click Reactions for Anticancer Applications

Related Articles

01 Mar, 2025

Geometric Symmetry and Structural Integrity in Ancient Indian Temples: A Computational Analysis

Read More
21 Feb, 2025

Synthesis and Characterization of Biodegradable plastic monomer from Castor oil Using FeCl3 as an Eco-Friendly and Inexpensive Catalyst

Read More
30 Jan, 2025

Modernization and Mechanization: The Decline of Traditional Folk Arts in India

Read More
25 Dec, 2024

Ethnopharmacological and Toxicological Perspectives: Decoding the Unique Nature of Manchineel (Hippomane mancinella) L.

Read More
Impact Factor
8.01 (Year 2024)
UGC Approved
Journal no 47859

Join Our IPN

IJIRT Partner Network

Submit your research paper and those of your network (friends, colleagues, or peers) through your IPN account, and receive 800 INR for each paper that gets published.

Join Now

Latest Publication

Archive

View More

Recent Conferences

NCSEM 2024

National Conference on Sustainable Engineering and Management - 2024 Last Date: 15th March 2024

Submit inquiry