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Formulation and Evaluation of Niosomes Loaded Bacopa Monnieri for Enhanced Transdermal Delivery

  • Unique Paper ID: 172801
  • Volume: 11
  • Issue: 9
  • PageNo: 927-935
  • Abstract:
  • In India, bacopa monnieri, also referred to as "brahmi," is a traditional medicinal plant. Since its active compounds, such as bacosides, are thought to be important in these processes, bacopa monnieri is thought to promote wound healing primarily through its antioxidant and anti-inflammatory properties, which can reduce free radical damage, enhance collagen production, stimulate fibroblast migration, and promote angiogenesis within the wound site, leading to faster wound closure and improved tissue repair. A topical antioxidant preparation based on niosomes was created in order to improve the stability of active ingredients and address the issue of their poor penetration into skin layers. This study's objective was to create and assess herbal formulations, such as niosomal gel that included extract from Bacopa monnieri. Niosomal formulation were prepared using various surfactants (span20, span60, span80) in the presence of cholesterol in different ratios (1:2, 1:3) by thin film hydration technique. They were evaluated for particle size, drug content, zeta potential, entrapment efficiency and in vitro drug release. Optimized formulation of niosomal suspension F4 using cholesterol and span 60 in the ratio 1:3 shows higher entrapment efficiency, In vitro rug release and drug content. The optimized formulation was formulated as topical gel using carbopol934 in different concentration and evaluated for pH, viscosity, drug content, Spreability, stability study. Optimized formulation of niosomal topical gel (A2) showed higher drug content 93.80%. It was concluded that niosomal topical gel is viable alternative for conventional gel and provide localized drug delivery and ability to sustain drug release.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 9
  • PageNo: 927-935

Formulation and Evaluation of Niosomes Loaded Bacopa Monnieri for Enhanced Transdermal Delivery

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8.01 (Year 2024)
UGC Approved
Journal no 47859

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