Author Login IJIRT Partner Network (IPN) Login

FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF ONDANSETRON HCl BUCCAL FILM BY UING NATURAL POLYMER

  • Unique Paper ID: 173134
  • Volume: 11
  • Issue: 9
  • PageNo: 1993-2007
  • Abstract:
  • The study aimed to develop oral dissolving films of ondansetron HCl to enhance therapeutic efficacy and improve patient compliance by addressing the limitations of conventional and parenteral formulations. Ondansetron HCl, an antiemetic, is widely used for managing chemotherapy and radiotherapy-induced vomiting, as well as postoperative and drug-induced nausea. Oral dissolving films were fabricated via the solvent casting method using varying proportions of Pectin, Xanthum gum, Sodium alginate and Acacia as polymeric bases. The films underwent evaluation for physicochemical properties, drug release, and disintegration. The optimized formulation, F4, demonstrated superior drug release (71.17% in 7 minutes), uniform thickness, high folding endurance (>300), and a buccal cavity-compatible surface pH. The release profile followed the trend F4 > F2 > F5 > F1 > F6 > F3 > F7 > F8, with F3 also exhibiting the highest drug content and the shortest disintegration time. These findings indicate that films with higher Acacia concentrations out performed rapid release of drug, making them a promising option for rapid and effective delivery of ondansetron HCl.
Download article email to a friend

Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 9
  • PageNo: 1993-2007

FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF ONDANSETRON HCl BUCCAL FILM BY UING NATURAL POLYMER

Related Articles

Impact Factor
8.01 (Year 2024)
UGC Approved
Journal no 47859

Join Our IPN

IJIRT Partner Network

Submit your research paper and those of your network (friends, colleagues, or peers) through your IPN account, and receive 800 INR for each paper that gets published.

Join Now

Latest Publication

Archive

View More

Recent Conferences

NCSEM 2024

National Conference on Sustainable Engineering and Management - 2024 Last Date: 15th March 2024

Submit inquiry