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Degradation Studies Of Alfuzosin Hydrochloride Using UV Spectroscopy

  • Unique Paper ID: 173480
  • Volume: 11
  • Issue: 10
  • PageNo: 399-406
  • Abstract:
  • The degradation studies of Alfuzosin HCl were conducted to evaluate its stability under various stress conditions using UV spectroscopy. The drug was subjected to acidic, alkaline, oxidative, thermal, and photolytic conditions to simulate different environmental factors that could impact its stability. UV spectroscopy was utilized to observe alterations in the absorption spectrum of the drug, facilitating the identification of degradation products and the evaluation of degradation extent. The findings indicated that the linearity range for Alfuzosin hydrochloride was between 100-500 ng/ml at a wavelength of 245 nm. The correlation coefficient for Alfuzosin hydrochloride was determined to be 0.999. The detection limit was established at 1 ng/ml, while the quantification limit was set at 100 ng/ml. The percentage relative standard deviation (RSD) for interday and intraday precision was calculated to be 0.2441 and 0.2083, respectively. The analysis indicated that the concentration of degradation products of Alfuzosin hydrochloride was 77.1% following acid hydrolysis, 85.1% after oxidation, and 94% due to photolytic degradation. Consequently, the method developed for the estimation of Alfuzosin hydrochloride in pharmaceutical dosage forms and in bulk is characterized as straightforward, precise, reproducible, and cost-effective.
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  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 10
  • PageNo: 399-406

Degradation Studies Of Alfuzosin Hydrochloride Using UV Spectroscopy

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