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A Review on Matrix Tablets to Treat Pulmonary Arterial Hypertension

  • Unique Paper ID: 179955
  • Volume: 11
  • Issue: 12
  • PageNo: 8937-8940
  • Abstract:
  • Pulmonary arterial hypertension (PAH) is a serious disease of the arteries connecting the heart to the lungs (the pulmonary arteries). As PAH develops, blood flow through the pulmonary arteries is restricted and the right side of the heart is put under increasing strain to pump blood through to the lungs. This leads to the main symptoms of PAH – breathlessness, chest tightness limited exercise capacity and fatigue. Pulmonary Arterial Hypertension (PAH) is a syndrome characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular overload and eventually to right ventricular failure and premature death. Matrix tablet as sustained release (SR) has given a new breakthrough for novel drug delivery system (NDDS) in the field of pharmaceutical technology. Hydrophilic polymer matrix is widely used for formulating an SR dosage form. The aim of drug delivery system is to provide therapeutic amount of drug to appropriate site in the body to achieve immediate therapeutic response and to maintain the desired drug concentration. Sustained release, sustained action, prolonged action, extended action are the terms used to identify drug delivery system that are designed to achieve a prolong therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. Hydroxy propyl methyl cellulose is widely used in oral, ophthalmic, nasal and topical pharmaceutical formulations. In oral products, hypromellose is primarily used as a tablet binder. This review primarily provides an overview of the progress of development of novel drug delivery system (NDDS) in the field of pharmaceutical technology and the characterization of matrix tablets evaluation as a quality control to ensure safety and efficacy of drug loaded matrix tablets and designed product meet its intended purpose.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 12
  • PageNo: 8937-8940

A Review on Matrix Tablets to Treat Pulmonary Arterial Hypertension

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