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Study of Leachability and Interaction Of Di Isononyl Phthalate with Meropenem and Levetiracetam Using HPTLC

  • Unique Paper ID: 180116
  • Volume: 12
  • Issue: 1
  • PageNo: 170-173
  • Abstract:
  • Aim : To develop a High Performance Thin Layer Chromatographic technique which is capable of detecting and quantifying a IV line plasticizer Diisononyl phthalate (DINP), Meropenem and Levetiracetam. The components were separated using stationary phase Merck Pre-coated TLC plates with silica gel 60F254. The mobile phase employed consisted of Ethylacetate: methanol: water: formic acid (7:4:1:3 v/v/v/v) for meropenem, toluene: acetone: methanol (6:2:2 v/v/v) for levetiracetam. IV line tubes were used to study leaching and interaction of DINP with drugs in specific time frame. Evaluation was done using Peak area. Method is validated and linearity is observed from 250 to 1500 ng/band for Meropenem and Levetiracetam. Interday and intraday precision values were within the limit of 2% RSD. The peak area of components used to evaluate. The research study ensures leaching of di isononyl phthalate plasticizer in presence of lipophilic drugs like meropenem and levetiracetam. The concentration of drugs remains unaltered, however leaching of plasticizer increased considerably while it is present with drugs lead to adverse effects.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 12
  • Issue: 1
  • PageNo: 170-173

Study of Leachability and Interaction Of Di Isononyl Phthalate with Meropenem and Levetiracetam Using HPTLC

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