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@article{157908,
        author = {Manthan Prajapati and Kenil Choksi and Madhav Oza and Jaydev Patel and Mansi Bhagat},
        title = {Neurofibromatosis type-1: A Narrative Review on Epidemiology, Clinical Manifestations and Management},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {9},
        number = {8},
        pages = {242-245},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=157908},
        abstract = {One in 2,500 persons worldwide have neurofibromatosis type 1 (NF1), a prevalent neurogenetic condition. There is a 50% chance of passing it on to their offspring because it is an autosomal dominant disorder. Café-au-lait macules, neurofibromas or plexiform neurofibroma, skinfold freckling, an optic pathway tumour, two or more iris hamartomas, a distinctive bone lesion, or a first-degree relative with NF1 are required for the diagnosis of NF1. Café-au-lait spots, freckled skin folds, generalised hyperpigmentation, blue-red and pseudoatrophic macules, plexiform neurofibroma, juvenile xanthogranuloma, glomus tumour, melanoma, nevus anemicus, and pruritus are examples of cutaneous manifestations of NF1. Learning difficulties and attention deficit hyperactivity disorder (ADHD) are among the NF1 non-cutaneous manifestations, as are orthopaedic, neurologic/psychiatric, ophthalmologic, and other conditions. Treatment options for NF1 include genetic counselling, referrals to other experts, and therapies like speech, occupational, or physical therapy. To create new treatments for NF1, ongoing research is being done.},
        keywords = {Neurofibromatosis type-1, neurogenetic disorder, rare disease, Cutaneous manifestations},
        month = {},
        }