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@article{160456,
        author = {Ahire Kuldip Kiran  and Sakrudkar Angad Ramraj  and Ansari R.A  and Dr .Santosh Jain},
        title = {Solubility Enhancement Methods},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {10},
        number = {1},
        pages = {668-674},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=160456},
        abstract = {Solubility is not to be confused with the ability to dissolve or liquefy a substance, since this process may occur not only because of dissolution but also because of a chemical reaction. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Among all newly discovered chemical entities about 40% drugs are lipophilic and fail to reach therapeutic range due to their poor water solubility. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. This present review details about the different approaches used for the enhancement of the solubility of poorly water-soluble drugs include particle size reduction, nanonization, pH adjustment, solid dispersion, complexation, co‐solvency, hydrotropy etc. The purpose of this article is to describe the techniques of solubilization for the attainment of effective absorption and improved bioavailability.
Solubility is defined in quantitative terms as the concentration of the solute in a saturated solution at a certain temperature and in qualitative terms, it may be defined as the spontaneous interaction of two or more substances to form a homogeneous molecular dispersion. A saturated solution is one in which the solute is in equilibrium with the solvent. The solubility of a drug may be expressed as parts, percentage, molarity, molality, volume fraction, and mole fraction. Drug solubility is the maximum concentration of the drug solute dissolved in the solvent under specific condition of temperature, pH and pressure. The drug solubility in saturated solution is a static property where as the drug dissolution rate is a dynamic property that relates more closely to the bioavailability rate . The solubility of a drug is described in various descriptive terms which is based on the amount of drug dissolved in solvent and discussed in.},
        keywords = {Solubility Enhancement Methods},
        month = {},
        }