ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FAVIPIRAVIR BY UV SPECTROPHOTOMETRIC METHOD

  • Unique Paper ID: 162308
  • PageNo: 227-232
  • Abstract:
  • Analytical chemistry is a branch of chemistry that deals with the separation, identification and determination of components in a sample. Aim of the present work was to develop a simple, rapid and economical method for estimation of Favipiravir by UV-Visible spectrophotometric method. Favipiravir is a modified pyrazine analogue that was initially approved for therapeutic use in resistant case of influenza. The linearity was studied by performing three independent analyte curves with six concentration levels ranging between (2-12μg/ml). The recovery results showed that the proposed method has an acceptable level of accuracy for Favipiravir which is from 50-150%. The %RSD values of precision was found to be < 2. LOD was found to be 0.0178 whereas LOQ was 0.054. The method was validated as per the guidelines laid by ICH. The results of validation test were found to be satisfactory and therefore this method can be applied successfully to analysed drug formulation.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{162308,
        author = {KRISHNAPHANISRI PONNEKANTI and Addanki Anusha  and MD Imamuddin and Nandi Srinitha and Pathlavath Vijay  and Sandhiri Sravani},
        title = {ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FAVIPIRAVIR BY UV SPECTROPHOTOMETRIC METHOD},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {10},
        number = {9},
        pages = {227-232},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=162308},
        abstract = {Analytical chemistry is a branch of chemistry that deals with the separation, identification and determination of components in a sample. Aim of the present work was to develop a simple, rapid and economical method for estimation of Favipiravir by UV-Visible spectrophotometric method. Favipiravir is a modified pyrazine analogue that was initially approved for therapeutic use in resistant case of influenza. The linearity was studied by performing three independent analyte curves with six concentration levels ranging between (2-12μg/ml). The recovery results showed that the proposed method has an acceptable level of accuracy for Favipiravir which is from 50-150%. The %RSD values of precision was found to be < 2. LOD was found to be 0.0178 whereas LOQ was 0.054. The method was validated as per the guidelines laid by ICH. The results of validation test were found to be satisfactory and therefore this method can be applied successfully to analysed drug formulation. },
        keywords = {},
        month = {},
        }

Cite This Article

PONNEKANTI, K., & Anusha, A., & Imamuddin, M., & Srinitha, N., & Vijay, P., & Sravani, S. (). ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FAVIPIRAVIR BY UV SPECTROPHOTOMETRIC METHOD. International Journal of Innovative Research in Technology (IJIRT), 10(9), 227–232.

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