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@article{165169,
        author = {DIPIKA CHAVDA and Rinkal Chaudhary and Vaishali Thakkar1},
        title = {QBD BASED IN-VITRO FUNCTIONALITY ASSESSMENT OF DEVELOPED FOAM BASED VAGINAL DRUG DELIVERY SYSTEM},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {1},
        pages = {2651-2662},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=165169},
        abstract = {Background: vulvovaginal candidiasis (VVC) is a yeast infection caused by the fungus Candida at the opening of the vagina. 75% of women suffer from vaginitis at least once in their lifetimes.
Objective: The present research aims to develop and assess foam- based vaginal formulation for better patient compliance.
Methods: HPMCE5 and HPMCK4M containing mucoadhesive foam formulation of Clotrimazole was prepared by using lactic acid, polysorbate80, lecithin and water. QbD based in-vitro functionality assessment of developed foam based vaginal drug delivery system included viscosity, foam spreadability and foam stability. In vitro drug release was performed and the optimized batch was subjected for stability study.
Result: Clotrimazole was found to be compatible with selected polymers in compatibility studies. 32 factorial design was successfully used to optimized foam stabilizers such as 0.51 gm HPMC E5, 0.50 gm HPMC K4M and 0.2 ml polysorbate 80. F4 batch is give a higher Viscosity and drug release due to high concentration of polysorbate 80 and HPMC E5. There was no significant difference found in Drug content and % CDR during stability study.
Conclusion: Optimized foam formulation showed better spreadability with lower surface tension and released the drug within 20 minutes. Subsequently it reduced dosing frequency and provide quick relief.},
        keywords = {Foam Formulation, HPMC E5, HPMC K4M, QbD, Factorial Design},
        month = {November},
        }