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@article{166595,
        author = {Mr. Mayur K. Lohkare and Mr. Rahul N. Jadhav and Mr. Gulab S. Shinde and Ms. Sohini A. Ganguly and Mr. Nilesh D. Sonawane},
        title = {RECENT TRENDS IN INSULIN DELIVERY BY MEANS OF TECHNOSPHERE DRUG DELIVERY MECHANISM: A REVIEW},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {2},
        pages = {1293-1301},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=166595},
        abstract = {Technosphere/Insulin [TI] is formulation of regular human insulin designed for efficient transport across respiratory epithelium into the circulation. The drug carrier mechanism achieves a fast systemic insulin uptake (maximum time 15-20 min.), a fast onset of action (maximum activity 25-30 min.) and short duration of action (2 h). Bioavailability relative to subcutaneous injection was established to be between 30 and 50% with a linear dose response relationship and low variability. In all published short-term study, TI was well tolerated. Provided a reliable long term safety profile, TI may become a suitable alternative to subcutaneous injection for prandial insulin delivery. TI offers the possibility of new treatment regimens, especially in patient with type 2 diabetes.},
        keywords = {diabetes mellitus, inhalation, pulmonary insulin, technosphere },
        month = {July},
        }