The Pharmacology of Neuroprotection: A Review of Drugs and Targets for Neurodegenerative Diseases

  • Unique Paper ID: 166670
  • Volume: 11
  • Issue: 2
  • PageNo: 1520-1524
  • Abstract:
  • Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are characterized by progressive neuronal loss and functional decline. The development of neuroprotective strategies aims to prevent or slow this neurodegeneration. This review discusses the current pharmacological agents and their molecular targets for neuroprotection in these diseases, focusing on antioxidants, mitochondrial protectants, glutamate receptor antagonists, anti-inflammatory agents, neurotrophic factors, cholinesterase inhibitors, immunomodulatory therapies, autophagy modulators, epigenetic modifiers, calcium channel blockers, stem cell therapy, and gene therapy. Advances in clinical trials, combination therapies, biomarker development, and precision medicine are also explored.

Copyright & License

Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{166670,
        author = {Kishan kumar Gaur and kajal Diwevedi and Neha Srivastav and Pragati Pandey and Anjali Saxena},
        title = {The Pharmacology of Neuroprotection: A Review of Drugs and Targets for Neurodegenerative Diseases},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {2},
        pages = {1520-1524},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=166670},
        abstract = {Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are characterized by progressive neuronal loss and functional decline. The development of neuroprotective strategies aims to prevent or slow this neurodegeneration. This review discusses the current pharmacological agents and their molecular targets for neuroprotection in these diseases, focusing on antioxidants, mitochondrial protectants, glutamate receptor antagonists, anti-inflammatory agents, neurotrophic factors, cholinesterase inhibitors, immunomodulatory therapies, autophagy modulators, epigenetic modifiers, calcium channel blockers, stem cell therapy, and gene therapy. Advances in clinical trials, combination therapies, biomarker development, and precision medicine are also explored.},
        keywords = {Neuroprotection, Neurodegenerative Diseases, Pharmacology, Drugs, Targets, Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis.},
        month = {July},
        }

Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 2
  • PageNo: 1520-1524

The Pharmacology of Neuroprotection: A Review of Drugs and Targets for Neurodegenerative Diseases

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