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@article{166673,
        author = {Uma kumari and Avantika Sanjay},
        title = {INTEGRATED PROTEOMICS NETWORK ANALYSIS AND PHYLOGENETIC ANALYSIS ON SMALL SPOTTED CATSHARK CD8 ALPHA},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {2},
        pages = {1553-1561},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=166673},
        abstract = {The aim of this project is to comprehensively analyze the CD8α protein of the small spotted catshark (Scyliorhinuscanicula) using integrated proteomic network analysis and phylogenetic techniques. Using bioinformatics tools such as RasMol, PyMOL, InterPro, Jalview, T-Coffee, SAVES Server, PROCHECK, ERRAT,  COBALT and BioPython etc we performed sequence scanning, structure visualization, network analysis and modeling. validation Our findings revealed conserved regions and critical functional motifs of the CD8α protein, highlighted by the evolutionary conservation observed in multiple sequence alignments and phylogenetic analysis. Hydrogen bond analysis and molecular weight calculations provided additional structural insights, while network analysis highlighted potential protein-protein interactions. Structural models validated using ERRAT and Ramachandran plots confirmed the accuracy and reliability of our predictions. This integrated approach not only advances our understanding of CD8α in the small-spotted catshark, but also sets a precedent for similar studies in other species, making important contributions to the fields of immunology and developmental biology},
        keywords = {Homology modelling, Sequence similarity, CD8 alpha, Sequence Alignment, Errat, Biopython},
        month = {July},
        }