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@article{157287,
        author = {Uma Kumari and Tanishka Uttam},
        title = {Protein Sequence Analysis and Homology Modeling Of the Human T-cell Leukemia},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {9},
        number = {6},
        pages = {388-398},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=157287},
        abstract = {The human deals with many diseases emerging from many sources, but only a few of them are curable. Diseases caused by viruses as sources are the most difficult ones to deal with. HTLV-1(Human T cell lymphotropic/leukaemia type-1) comes under retrovirus classification.In most cases, no sure cure is present till nowadays. The current status the estimated at 5 million to 10 million. The causative agents of both adult T cell leukaemia (ATL) and HTLV-1 Associated Myelopathy Spastic Paraparesis (HAM/TSP). The main geographical regions are the Southwestern part of Japan, Sub-Saharan Africa and South America. The initial stage of infection is unknown but certain studies show that the virus attack CD4+ T cells, CD34+, B lymphocytes, T lymphocytes and hematopoietic progenitor cells etc. Through an In-silicon approach for designing the drug against this protein expressed by HTLV-1 cells using bioinformatics database and software.  Designing of ligands for substrate (HTLV-1) was performed.It was identified that the drug Allopathy Glatiramer, Plant-based drug Oleandrin and antibodies Doxycycline showed partially able to cure the T cell leukaemia virus replication protein structure.},
        keywords = {HTLV-1; T cell leukemia; carcinogenesis; miRNAs, Homology modelling, Molecular Docking,Structural Analysis},
        month = {},
        }