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@article{169064,
        author = {DILLIP KUMAR MOHAPATRA and DEEPIKA RANI PANIGRAHI and SOMEZEET PANDA and RAJESH KUMAR NAYAK},
        title = {STUDY OF ANTIDIABETIC ACTIVITY OF Dendrocalamus strictus (SHOOTS) EXTRACT IN HIGH FAT DIET INDUCED RATS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {6},
        pages = {441-445},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=169064},
        abstract = {Objectives: - The present study has been undertaken to investigate the antidiabetic potential of methanol extract of Dendrocalamus strictus in high fat diet induced diabetic rats.
Methods:-1.Preparation of extract – Collection, authentication, cleaned and dried. Extraction- Dried shoots are subjected to solvent extraction (e.g., using methanol)
2. Animal Model- Rats are fed a high fat diet for several weeks (usually 6-8 weeks) to induce insulin resistance and hyperglycemia, mimicking type-2 diabetes.
3. Experimental design –Groups- Normal control(std diet),Diabetic control(high fat diet), diabetic + low dose of extract , diabetic + high dose of extract, positive control(Glibenclamide)
4. Treatment- The extract is administered orally for a specified duration. Doses are determined based on preliminary studies.
5. Assessment- Blood glucose levels: Measured periodically. OGTT: Performed to assess glucose handling. Insulin levels: measured using ELISA kits. 
Results: - Blood glucose levels: Significant reduction in blood glucose levels in the methanolic extract compared to the diabetic control. OGTT: Improved glucose tolerance in methanolic extract. Insulin levels: Increased insulin sensitivity secretion. 
Conclusion:-From the toxicity study it was observed that methanolic extract of Dendrocalamus strictus was nontoxic up to the dose of 2000 mg/kg body weight. In this study, animals received continuous oral administration for a period of 15 days at the doses of 200 mg/kg and 400 mg/kg body weight. The effect was compared with oral dose of 0.5 mg/kg Glibenclamide. The results showed that the shoots extract exhibits significant antidiabetic activity in high fat diet induced diabetic rats, suggesting its potential as a natural therapeutic agent for managing diabetes.  Further studies including clinical trials would be necessary to confirm its efficacy and safety in humans.},
        keywords = {OGTT, HDL, LDL, GOD-POD, Dendrocalamus strictus},
        month = {November},
        }