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@article{170169,
        author = {Aditya Raut and Suyash Palwe and Siddesh Jagtap and Prof.Nilesh Wadkar},
        title = {A comprehensive analysis of Peptic ulcer and Nerium Oleander as an anti-inflammatory agent and Medicinal plants have been traditionally used for their anti-ulcer properties.},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {6},
        pages = {3198-3211},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=170169},
        abstract = {Peptic ulcers are a type of ulcer that occurs in the stomach or upper intestines, characterized by tissue loss and epigastric pain. Important elements in the pathophysiology of PUD include defensive elements like mucus, prostaglandins, bicarbonate, and nitric oxide, as well as inflammatory elements like pastic acid and pepsin. Traditional risk factors for PUD include spicy foods, Helicobacter pylori, NSAIDs, stress, alcohol, and smoking. However, research has also identified endogenous chemicals that play a role in the development of intestinal diseases.
Oleander has various medicinal properties and has been used in folk medicine to treat various diseases. The study aims to investigate the effect of methanolic leaf extract of oleander on pyloric ligation and indomethacin-induced ulcer in rats.
Helicobacter pylori is a gram-negative, motile, flagellated bacillus that causes inflammation of the mucosa, neutralization of the acidic environment, injection of bacterial proteins and cytotoxins, stimulation of inflammatory response, and production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). NSAIDs are widely used to treat various conditions, but long-term use can cause stomach pain and increase the risk of peptic ulcers. A number of processes contribute to the pathophysiology of NSAID-induced peptic ulcers, including increased lipid peroxidation, suppression of prostaglandin synthesis, disruption of gastric acid secretion and mucosal blood flow, suppression of mast cell and leukocyte activation, suppression of platelet aggregation and thromboxane production, and inhibition of mast cell and leukocyte activation. Ethanol-induced gastric ulcers have several mechanisms of action, including reduced mucus production, reduced blood flow to the mucosa, and increased inflammation.},
        keywords = {Peptic ulcer, H.pylori, Methanolic extract of leaves, NSAID, Ethanol induced gastric ulcer, Pyloric ligation induced gastric ulcer, Indomethacin induced gastric ulcer)},
        month = {November},
        }