FABRICATION OF GelMA-FIBROIN CONJUGATED MATERIALS WITH GYMNEMA SYVESTRE EXTRACT TO TARGET COLON CANCER AND ACUTE WOUND

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Meena Duraisamy; Megavannan rajaram

FABRICATION OF GelMA-FIBROIN CONJUGATED MATERIALS WITH GYMNEMA SYVESTRE EXTRACT TO TARGET COLON CANCER AND ACUTE WOUND

Authors: Meena Duraisamy, Megavannan rajaram

Unique Paper ID: 172488
Volume: 11
Issue: 9
PageNo: 190-201

Keywords: Gymnema sylvestre GelMA Fibroin Colon cancer

Abstract:
Background: In the present study revealed that concentration of Leaf extract+GelMA+fibroin exhibited a greater result of anti-cancer activity, speed of wound healing, anti-inflammatory and cyto-compatibility. Methods: Further FT-IR analysis was performed to found the functional groups present in extract, Fibroin, GelMA and its complex. Morphometric characterization was achieved by SEM analysis. Results: The cytotoxicity of colon cancer cell lines were analyzed with all ingredients by MTT assay and found its IC50 at (24µg/mL) leaf extract, (16µg/Ml) GelMA, (12µg/mL) Fibroin and (3µg/mL) LE+GelMA+Fibroin. Thus, therapeutic agent of LE+GelMA+fibroin complex showed best results of faster re-epithelialization as well as increased collagen expression, due to better and rapid healing through synergistic effect of formulated biomaterial in vitro and in vivo. We found that the wound healing or closure in 7th day was no significant within individual or complex treatments. However, the wound healing was started. We found at day 14th -21st the wound contraction in wounds treated with Betadine was 5%, plant extract was 64%, GelMA was 69%, Silk fibroin was 78% and Leaf extract+GelMA+fibroin composite were 85%. This preliminary study using plant extract, silk fibroin and GelMA composition have a potential activity against post operated colon cancer cell line and rat. Conclusion: Thus, the present findings validated the low toxicity and high therapeutic potentials of LE+GelMA+fibroin, which may provide a convincing evidence of LE+GelMA+fibroin as new potential drug for colon cancer and acute wound. In future it will be a good combination to carry nanomedicine towards post operated wounds in various cancer models.

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ISSN: 2349-6002
Volume: 11
Issue: 9
PageNo: 190-201

FABRICATION OF GelMA-FIBROIN CONJUGATED MATERIALS WITH GYMNEMA SYVESTRE EXTRACT TO TARGET COLON CANCER AND ACUTE WOUND

Available:https://ijirt.org/article?manuscript=172488

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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