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@article{172870,
        author = {Dr.Christopher Vimalson.D and Dr. S. Vijayshree and T.Gowrishankar and Dr.M.Alagarraja and Lakshmi.D and Raju.R and Vasanthkumar.S and Subha shree.R},
        title = {FORMULATION AND EVALUATION OF KETOCONAZOLE NIOSOMAL GEL},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {9},
        pages = {1762-1768},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=172870},
        abstract = {Niosomes are an innovative drug delivery system composed of non-ionic surfactant vesicles that encapsulate medications. These nanometric vesicles are produced by hydrating synthetic non-ionic surfactants along with or without cholesterol. Structurally similar to liposomes, niosomes offer additional advantages, making them suitable carriers for amphiphilic and lipophilic drugs. This study aimed to formulate and evaluate a ketoconazole niosomal gel for controlled drug delivery to enhance therapeutic efficacy through sustained release. The objectives included optimizing formulation variables, assessing drug entrapment efficiency, and conducting stability studies under different storage conditions. Ketoconazole, cholesterol, Tween 20, and propylene glycol were used, and the ether injection method was employed for formulation. Characterization studies evaluated physical appearance, pH, viscosity, drug content uniformity, entrapment efficiency, and in vitro drug diffusion. Results indicated significant improvements in drug entrapment efficiency and sustained release, highlighting the controlled release mechanism. Stability studies confirmed that the niosomal gel maintained its properties over time, indicating potential for long-term use. The ketoconazole niosomal gel formulation showed promising results by enhancing antifungal activity through a controlled drug delivery system. The method effectively incorporated the poorly water-soluble drug with high entrapment efficiency. Prolonged drug release from the niosomal gel is expected to reduce administration frequency and adverse effects, enhancing patient compliance. In conclusion, the ketoconazole niosomal gel could offer sustained therapeutic benefits and improved skin penetration compared to conventional formulations.},
        keywords = {Niosomes, Controlled Drug Delivery, Ketoconazole, Antifungal Activity.},
        month = {February},
        }