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@article{173134,
        author = {Chandrika Khanolkar and Tushar Rukari and Gauri Bhivshet and Rohan Barse and Vijay Jagtap},
        title = {FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF ONDANSETRON HCl BUCCAL FILM BY UING NATURAL POLYMER},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {9},
        pages = {1993-2007},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=173134},
        abstract = {The study aimed to develop oral dissolving films of ondansetron HCl to enhance therapeutic efficacy and improve patient compliance by addressing the limitations of conventional and parenteral formulations. Ondansetron HCl, an antiemetic, is widely used for managing chemotherapy and radiotherapy-induced vomiting, as well as postoperative and drug-induced nausea. Oral dissolving films were fabricated via the solvent casting method using varying proportions of Pectin, Xanthum gum, Sodium alginate and Acacia as polymeric bases. The films underwent evaluation for physicochemical properties, drug release, and disintegration. The optimized formulation, F4, demonstrated superior drug release (71.17% in 7 minutes), uniform thickness, high folding endurance (>300), and a buccal cavity-compatible surface pH. The release profile followed the trend F4 > F2 > F5 > F1 > F6 > F3 > F7 > F8, with F3 also exhibiting the highest drug content and the shortest disintegration time. These findings indicate that films with higher Acacia concentrations out performed rapid release of drug, making them a promising option for rapid and effective delivery of ondansetron HCl.},
        keywords = {Ondansetron HCl, Antiemetic, Acacia, Solvent Casting.},
        month = {February},
        }