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@article{173158,
        author = {Baralee Seenprachawong},
        title = {Does High-Flow Nasal Cannula reduce re-intubation among high-risk patients in real practice?},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {9},
        pages = {2504-2509},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=173158},
        abstract = {Background: Re-inbutation in high- risk patients leading for prolonged hospital stays and increased in mortality rate. HFNC after extubation had better outcome for lowering rate of re-intubation in low-risk patients rather than conventional oxygen therapy, but no sufficient of clinical evidence in high-risk groups.
Objective: To demonstrate that HFNC reduces re-intubation rate in high-risk patients compared with conventional oxygen therapy.
Methods: A single-center, prospective cohort study was conducted between January and December 2023. Total 200 patients with one or more from the high- risk criteria for extubation were enrolled. The primary outcome was re-intubation within 72 hours. Secondary outcomes included time to re-intubation, post-extubation respiratory failure, ventilator-associated pneumonia (VAP), hospital length of stay (LOS) and mortality rate.
Results: A total of 200 patients were enrolled, with 100 receiving HFNC and 100 receiving COT. More patients in the HFNC group had cerebrovascular disease, airway patency issues, poor expectoration, and a longer duration of mechanical ventilation, which correlated with a higher incidence of respiratory tract infections, the leading cause for the need for mechanical ventilation. Re-intubation was required in 14% of the HFNC group and 11% of the COT group, but the time to re-intubation did not differ between the groups. The incidence of ventilator-associated pneumonia (VAP) was higher among re-intubated patients in the HFNC group (13% vs. 5%), leading to prolonged hospital stays and increased mortality rates, although these differences were not statistically significant.
Conclusion: Among patients at high risk for re-intubation, HFNC did not reduce the risk of re-intubation within 72 hours compared to COT.},
        keywords = {HFNC, COT, Re-intubation, High-risk patients},
        month = {February},
        }