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@article{173393,
        author = {Mrs. Anjusha M K and Colin K Varghese and Nasrin P A and Niya Fathima and Thasny P N},
        title = {IN-VITRO ANTISPASMODIC EFFECTS OF PSIDIUM GUAJAVA L. LEAVES USING ISOLATED CHICK ILEUM},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {10},
        pages = {246-252},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=173393},
        abstract = {Background-An antispasmodic drug is a medication used to relieve or prevent spasms or involuntary muscle contraction in the body. Acetylcholine is a neurotransmitter that can indeed cause muscle contraction or spasms under certain circumstances. Psidium guajava is a commercially available plant that has been used commercially for its antispasmodic properties. 
Aim:
The study aims to access the antispasmodic activity of ethanolic extract in Psidium guajava comparison with Atropine using in vitro experimental models. 
Materials and methods:
Ethanolic extracts were prepared by the soxhlation method for the in vitro study, and isolated chick ileum was used. Chick ileum was suspended in an organ bath containing Tyrode solution at 37 0 C with adequate oxygen supply. The effect of Psidium guajava was studied on ileum contraction induced by acetylcholine compared with that of Atropine.
Results:
The mean percentage response was calculated for the ethanolic extract of Psidium guajava and Atropine.
Conclusion:
From this study, it was concluded that Psidium guajava extract has a significant antispasmodic activity compared to Atropine. These findings therefore raise hope for the development of a new antispasmodic drug with few side effects that may be useful in the treatment of conditions like dysenteries, the relief of cramps, abdominal distention, and postprandial lower abdominal discomfort associated with diarrhea which are common symptoms in patients with IBS. Antispasmodic activity can inhibit the muscle spasm with fewer side effects. Adverse effects associated with these agents are anticholinergic in nature.},
        keywords = {Antispasmodic, spasm, Psidium Guajava, Irritable bowel syndrome (IBS), Neurotransmitter, Plant extract, Diarrhea, Gastrointestinal disorder, Anti-inflammatory.},
        month = {March},
        }