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@article{174138,
        author = {Mohammed Arsh Sayyed and Mrs. Zeba Mohammed Fasihuddin Shaikh and Mr. Mujeeb Muhamadhusen Shaikh},
        title = {Nanoparticle-Based Drug Formulation for Solubility Enhancement: A Brief Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {10},
        pages = {2644-2646},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=174138},
        abstract = {One of the major challenges in pharmaceutical drug development is the poor water solubility of many active pharmaceutical ingredients (APIs), which significantly impacts their bioavailability and overall therapeutic effectiveness. Nanoparticle-based drug delivery systems have emerged as a promising strategy to overcome this limitation by enhancing solubility and dissolution rates. This review explores the application of the nanoprecipitation technique in the formulation of Ibuprofen nanoparticles, a widely used nonsteroidal anti-inflammatory drug (NSAID) that exhibits low aqueous solubility. The study emphasizes the role of polymeric stabilizers such as polyvinyl alcohol (PVA) and polyethylene glycol (PEG) in maintaining nanoparticle stability and preventing aggregation. Various analytical techniques, particularly UVa-Vis spectroscopy, were employed to assess solubility improvements through spectral shifts and changes in absorbance intensity. The results demonstrated a bathochromic shift and increased absorbance, confirming enhanced dissolution. Additionally, the formation of a colloidal suspension was validated by the Tyndall effect, further supporting the nanoparticle stability. The findings indicate that the nanoprecipitation method offers a simple, scalable, and cost-effective approach for improving the aqueous solubility of poorly soluble drugs. Future prospects include industrial-scale formulation, optimization of large-scale production techniques, and clinical applications of nanoparticle-based drug delivery systems to enhance therapeutic outcomes and patient compliance},
        keywords = {},
        month = {March},
        }