Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{177113,
        author = {NANDHAKUMAR.N and Lalitha.V and Parthiban.S and Krishnakumar.P and Selvarasu.P and Pradeep.P and Dr.Rathinavel.G},
        title = {Evaluation of Anxiolytic Activity of Ethanolic Leaf Extract of Gallium Odoratum Using Mice},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {177-190},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=177113},
        abstract = {The anti anxiety activity of ethanolic leaves extract of Gallium odoratum was determined by experimental animal models. The anxiolytic activity of the plant was studied using diazepam(3 mg/kg, orally) as standard and two different doses of extract (250 mg/kg, 500 mg/kg, oral) by using elevated plus maze, open field model, light-dark model, rota rod model. Phytochemical screening indicates the presence of alkaloids, flavonoids, tannins, phenols, saponins, terpenoids, steroids, and glycosides. From acute oral toxicity studies, reported that ethanolic extract of Gallium odoratum did not produce any toxicity or behavioral changes or mortality upto an oral dose of 2000 mg/kg in animals. The plant extract showed anxiolytic activity confirmed by number of entries and time spend in open arm increased in elevated plus maze, number of squares crossed and number of rearing was increased in open field model, time spent in light chamber and number of transition between two chambers was increased in light- dark model, time spent on rota rod and locomotor acivity was increased in rota rod model. The above studies have been concluded that the extract exhibit anxiolytic effect in experimental mice. So it supports the use of Gallium odoratum leaves extract as anxiolytic agents. Future studies will be focused on the neurobiological mechanisam of action and possible interaction on Gallium odoratum with classical neurotransmitters and phytoconstituent responsible for the observed central effects has to be isolated and identified.},
        keywords = {},
        month = {April},
        }