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@article{177320,
        author = {Mahi Warde and Lakshi Nandwana and Drishti Khandelwal},
        title = {Gene Drive for Invasive Species},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {450-454},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=177320},
        abstract = {As some rodents just appear in some places where they don’t belong creates unexpected harm to the people as well the other biotic organisms in the surrounding. Henceforth, the gene drive technology works as rescuer. Earlier days, toxication of rodents was the only option but now some technologies have come into the scenario which avoids unnecessary losing of the diversity and generates alternates for the same. First one is natural meiotic drive where a preferable chromosome is transmitted with unequal ratio which is generally greater than 50% , which is naturally transmitted with 50/50 ration in the offspring. Another one is clustered regularly interspersed short palindromic repeats (CRISPR) which comes under bacterial defence system. Cas9 enzyme is a protein which can cut the DNA at the specifies area dividing fit into two strands and this break can be repaired by cell’s natural DNA repair mechanism. Further allowing desired modifications to occur. The above stated technologies can restrict the offsprings to be predominantly male and hence reducing the chances of further reproduction. Hence, engineered mice developed out of these technologies possesses less threat to the environment.
Gene drive technology is emerging as a potentially powerful tool in combating vector-borne diseases – notably malaria. This study introduces an agent-based model (ABM) focused on the deployment of genetically engineered mosquitoes with gene drive (GEM) in Príncipe Island, Republic of São Tomé and Príncipe, an island nation in the Gulf of Guinea, West Africa. Grounded in empirical data from laboratory and field studies, our model forecasts the dynamics of mosquito populations central to devising efficacious GEM release strategies. The core objective is to evaluate the time required for GEMs to constitute 90% of the mosquito population and to elucidate their dispersal throughout the island. This research is instrumental in understanding GEM potential in controlling malaria vectors.},
        keywords = {},
        month = {May},
        }