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@article{178197,
        author = {RAHUL SHARMA and Dr. MOHIT KHANDELWAL},
        title = {Formulation and Evaluation of Fast Dissolving Tablets of Anti – Cholinergic Drugs},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {3133-3138},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=178197},
        abstract = {The objective of the present study was to formulate and evaluate fast dissolving tablets (FDTs) of Hyoscine Butylbromide, an anti-cholinergic drug used in the treatment of gastrointestinal disorders and motion sickness. Fast dissolving tablets are designed to disintegrate and dissolve rapidly in the oral cavity without the need for water, improving patient compliance, particularly in geriatric and pediatric populations. Hyoscine Butylbromide was selected due to its rapid onset of action requirement and favorable pharmacokinetics for buccal absorption.FDTs were prepared using the direct compression method incorporating various superdisintegrants such as croscarmellose sodium, sodium starch glycolate, and crospovidone in different concentrations. The pre-compression blend was evaluated for angle of repose, bulk and tapped densities, and compressibility index, while the tablets were subjected to post-compression evaluations including weight variation, hardness, friability, disintegration time, wetting time, drug content, and in vitro dissolution studies.Among the formulations developed, the batch containing 4% crospovidone showed the fastest disintegration time (less than 20 seconds) and complete drug release within 10 minutes. The results indicated that crospovidone significantly enhanced the disintegration and dissolution profile of Hyoscine Butylbromide FDTs. The optimized formulation exhibited acceptable physicochemical characteristics and potential for enhanced patient compliance.This study concludes that FDTs of Hyoscine Butylbromide can be effectively formulated by direct compression using superdisintegrants, offering a promising approach for rapid relief in conditions requiring anticholinergic therapy.},
        keywords = {FDT, ODT, Hysocine Butylbromide, API, COPD.},
        month = {May},
        }