Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{178304,
        author = {Gaytri Botre and Pallavi Kavitake and Ritesh Jagtap and Rutuja Jagdale and Snehal Koli and Shweta Jamdade and Dr. A.N. Panaskar},
        title = {Network Pharmacology Of colchicine},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {5611-5619},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=178304},
        abstract = {Network pharmacology is an arising interdisciplinary field that integrates systems biology, bioinformatics, and pharmacology to understand the complex relations between medicines, targets, and conditions. This study applies a network pharmacology approach to probe the multi-target mechanisms of colchicine, a natural alkaloid known for its anti-inflammatory parcels. Using tools similar as Swiss Target Prediction, Swiss ADME, and STRING, the molecular relations of colchicine were explored to identify crucial target genes and associated signaling pathways. Results revealed that colchicine interacts with pivotal seditious intercessors, including IL1B, IL10, and TNF, suggesting its nonsupervisory part in vulnerable-affiliated pathways similar as the NOD- suchlike receptor and cytokine- cytokine receptor commerce pathways. These findings punctuate the eventuality of colchicine in modulating multiple natural targets and pathways, supporting its remedial use in complex conditions similar as gout, cardiovascular diseases, and COVID- 19. The study demonstrates the mileage of network pharmacology in uncovering the mechanistic base of traditional medicines within ultramodern biomedical fabrics.},
        keywords = {Network Pharmacology, gene, colchicine, anti-inflammatory},
        month = {May},
        }