Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{179509,
        author = {Krutika Channe and Vibhakti Bagade and Ashwin Chauhan and Vaibhav Uplanchiwar and Vinod Thakre and Pallavi Sahare and Arti Darode and Ankita S. Mandekar},
        title = {A Central Regulator of Obesity & Cognitive Function},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {6794-6804},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=179509},
        abstract = {The gut microbiota and the central nervous system are connected by the microbiota-gut-brain axis (MGBA). This complex bidirectional communication network has a major impact on mental health, cognitive function, and metabolic control. The gut microbiota, which comprises billions of microorganisms, mediates vital functions like hunger regulation, neuroinflammation, and neurogenesis by interacting with host physiological systems through neurological, hormonal, and immunological pathways. Numerous neurodevelopmental, psychiatric, and neurodegenerative conditions, such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), anxiety, depression, Alzheimer's disease, and obesity, have been linked to dysbiosis, an imbalance in the makeup of gut microbes. The mechanics behind the MGBA are explained in this review, with a focus on how it affects cognitive function and exercise motivation. To improve mental health and gut health, we also look into therapeutic implications, such as microbial-based therapies, dietary adjustments, and lifestyle changes. By synthesising previous research, we demonstrate how targeting the MGBA may be a novel strategy for managing and preventing neuropsychiatric illnesses and related metabolic diseases. This could open the door for creative approaches to enhance general health and quality of life.},
        keywords = {Microbiota, Neuropsychiatric disorders, Cognitive function, Dysbiosis, Metabolic health, Obesity},
        month = {May},
        }