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@article{179710,
        author = {Jasmin Rashid Bagwan and Dr. H.V.Kamble and Mr. Mujeeb Muhamadhusen Shaikh},
        title = {Molecular Mechanisms and Therapeutic Targets in Cardiac Hypertrophy: A Systems Biology Perspective},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {8788-8793},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=179710},
        abstract = {Cardiac hypertrophy is a multifactorial and adaptive response of the myocardium to increased workload, but when sustained, it progresses to maladaptive remodeling and heart failure. A comprehensive understanding of the molecular signaling pathways and their interconnections is crucial for identifying precise therapeutic targets. This review integrates current knowledge from genomics, proteomics, transcriptomics, and metabolomics to dissect the key molecular mechanisms driving cardiac hypertrophy. Major signaling pathways such as MAPK, PI3K/Akt, Ca2+/calcineurin-NFAT, and G-protein coupled receptor (GPCR) cascades are analyzed within a systems biology framework. Furthermore, emerging roles of non-coding RNAs, epigenetic modifications, and oxidative stress are discussed. The review concludes with an exploration of existing and novel pharmacological interventions, including gene therapy, small molecule inhibitors, and natural products, offering new hope for reversing pathological hypertrophy.},
        keywords = {Cardiac hypertrophy, systems biology, signaling pathways, omics, therapeutic targets, non-coding RNA, oxidative stress.},
        month = {May},
        }