Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{179856,
        author = {Nallajeru Mounika and Mulla Ummer and V.N.V.Kalyan and M.Gayatri Ramya and Dr. Kamepalli Sujana},
        title = {Design, development, and in-vitro assessment of gastroretentive effervescent floating tablets of valsartan using various polymers},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {9043-9052},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=179856},
        abstract = {Objective: To formulate buoyant valsartan tablets by direct compression technique by hydroxypropyl methylcellulose K4M, hydroxypropyl methylcellulose K100, and Xanthan gum polymers to avoid side effects related to stomach and to obtain the controlled release of the drug. Methods: In this study, 12 formulations were made using different polymers in different proportions by direct compression. For all the formulations post-compression studies were studied. Results: Pre-formulation studies, Fourier Transform Infrared Spectroscopy, drug content, in-vitro drug release, and kinetics of drug release showed acceptable values. Solubility, melting point, and Ultraviolet analysis of the drug were within the acceptable ranges. Conclusion: Fourier Transform Infrared Spectroscopy shows the spectra of the drug alone and the combination of polymers and valsartan drug showed that there are no interactions between them and that shows they are compatible with each other. Based on release kinetics data and graphical analysis. F3 formulation has a polymer-drug ratio of 1.5:1 and shows a better release of the drug. Drug release data fitted into zero order kinetics. Korsemeyer-Peppas plot has an ‘n’ value that was in the range of 0.47-0.77. Valsartan tablets formulated with hydroxypropyl methylcellulose K4M demonstrate a better release of the drug for 12 hours. Drug releases through Non-Fickian diffusion. It shows good buoyancy. From all the data it can be concluded that it is feasible to design controlled-release gastroretentive effervescent buoyant valsartan tablets using HPMC K4M.},
        keywords = {Blood pressure, Effervescent, Polymers, Valsartan.},
        month = {May},
        }