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@article{179955,
        author = {Manoj Kumar Sharma and Garima Gupta and Rupesh Dudhe},
        title = {A Review on Matrix Tablets to Treat Pulmonary Arterial Hypertension},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {8937-8940},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=179955},
        abstract = {Pulmonary arterial hypertension (PAH) is a 
serious disease of the arteries connecting the heart to 
the lungs (the pulmonary arteries). As PAH develops, 
blood flow through the pulmonary arteries is restricted 
and the right side of the heart is put under increasing 
strain to pump blood through to the lungs. This leads to 
the main symptoms of PAH – breathlessness, chest 
tightness limited exercise capacity and fatigue. 
Pulmonary Arterial Hypertension (PAH) is a syndrome 
characterized by a progressive increase in pulmonary 
vascular resistance leading to right ventricular overload 
and eventually to right ventricular failure and 
premature death. 
Matrix tablet as sustained release (SR) has given a new 
breakthrough for novel drug delivery system (NDDS) in 
the field of pharmaceutical technology. Hydrophilic 
polymer matrix is widely used for formulating an SR 
dosage form. 
The aim of drug delivery system is to provide 
therapeutic amount of drug to appropriate site in the 
body to achieve immediate therapeutic response and to 
maintain the desired drug concentration. Sustained 
release, sustained action, prolonged action, extended 
action are the terms used to identify drug delivery 
system that are designed to achieve a prolong 
therapeutic effect by continuously releasing medication 
over an extended period of time after administration of 
a single dose. 
Hydroxy propyl methyl cellulose is widely used in oral, 
ophthalmic, nasal and topical pharmaceutical 
formulations. In oral products, hypromellose is 
primarily used as a tablet binder. 
This review primarily provides an overview of the 
progress of development of novel drug delivery system 
(NDDS) in the field of pharmaceutical technology and 
the characterization of matrix tablets evaluation as a 
quality control to ensure safety and efficacy of drug 
loaded matrix tablets and designed product meet its 
intended purpose.},
        keywords = {PAH, Matrix Tablet, NDDS.},
        month = {May},
        }