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@article{180057,
        author = {Atul Bopche and Himanshu Maurya and Jagdeesh Ahirwar and Jaspal Singh and Kavita Choudhary and Keval Pachoriya and Krit Pandey and Dr. Jagdish C. Rathi},
        title = {Development and Evaluation of an In Situ Nano Gel for Intranasal Delivery in Migraine Therapy},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {1},
        pages = {189-192},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=180057},
        abstract = {Migraine is a complex neurological disorder 
that often challenges effective therapeutics due to the 
limitations of conventional oral therapies, including 
poor bioavailability and delayed onset during acute 
migraine attacks. This research study focuses on the 
development of a thermo-responsive in situ nano gel 
incorporating sumatriptan-loaded transferosomes for 
intranasal delivery, aiming to overcome these 
limitations. Transferosomes were formulated using the 
thin-film hydration method with phospholipids, 
cholesterol, and Tween 80 to enhance flexibility and 
encapsulation efficiency. The optimized transferosome 
dispersion was embedded into a gel matrix, enabling a 
sol-to-gel transition at nasal temperatures. The 
formulation demonstrated nanoscale vesicle sizes, high 
drug entrapment, a biphasic release profile with 
sustained drug delivery over 12 hours, and favorable 
mucoadhesive properties. Stability studies confirmed 
the robustness of the system under varying storage 
conditions.  
Overall, the developed intranasal nano gel presents a 
promising, non-invasive platform for rapid and 
sustained migraine relief, with potential for improved 
patient adherence and therapeutic outcomes.},
        keywords = {Migraine, in situ gel, nano formulation,  intranasal drug delivery, drug release, permeation.},
        month = {May},
        }