Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{180116,
        author = {GANDHIMATHI M and KEERTHANA V},
        title = {Study of Leachability and Interaction Of Di Isononyl Phthalate with Meropenem and Levetiracetam Using HPTLC},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {1},
        pages = {170-173},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=180116},
        abstract = {Aim : To develop a High Performance Thin 
Layer Chromatographic technique which is capable of 
detecting and quantifying a IV line plasticizer 
Diisononyl phthalate (DINP), Meropenem and 
Levetiracetam. The components were separated using 
stationary phase Merck Pre-coated TLC plates with 
silica gel 60F254. The mobile phase employed consisted 
of Ethylacetate: methanol: water: formic acid (7:4:1:3 
v/v/v/v) for meropenem, toluene: acetone: methanol 
(6:2:2 v/v/v) for levetiracetam. IV line tubes were used 
to study leaching and interaction of DINP with drugs in 
specific time frame. Evaluation was done using Peak 
area. Method is validated and linearity is observed from 
250 to 1500 ng/band for Meropenem and 
Levetiracetam. Interday and intraday precision values 
were within the limit of 2% RSD. The peak area of 
components used to evaluate. The research study 
ensures leaching of di isononyl phthalate plasticizer in 
presence of lipophilic drugs like meropenem and 
levetiracetam. The concentration of drugs remains 
unaltered, however leaching of plasticizer increased 
considerably while it is present with drugs lead to 
adverse effects.},
        keywords = {Diisononyl phthalate, Leaching, drug  interaction, HPTLC},
        month = {May},
        }