A RARE PRESENTATION OF CENTRAL PONTINE MYELINOSIS SECONDARY TO HYPEROSMOLAR HYPERGLYCEMIA

  • Unique Paper ID: 180353
  • PageNo: 1289-1294
  • Abstract:
  • Central pontine myelinolysis (CPM) is a rare demyelinating disorder typically linked to rapid correction of chronic hyponatremia, but can also occur in other settings of abrupt osmotic shifts. We report a case of a 62-year-old male with poorly controlled diabetes mellitus who presented with sudden onset of dysarthria, dysphagia, and gait instability. Despite being normonatremic throughout hospitalization, he exhibited severe hyperglycemia and elevated serum osmolality. Neurological examination revealed cranial nerve and cerebellar dysfunction, and MRI confirmed CPM. This case highlights hyperosmolar hyperglycemic state (HHS) as an uncommon yet important cause of CPM, emphasizing the need for careful management of fluid and glucose levels in diabetic emergencies to prevent serious neurological complications

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{180353,
        author = {dr sanghamitra manepalli and dr. E. Sireesha and dr. K. Siva prasad},
        title = {A RARE PRESENTATION OF CENTRAL PONTINE MYELINOSIS SECONDARY TO HYPEROSMOLAR HYPERGLYCEMIA},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {1},
        pages = {1289-1294},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=180353},
        abstract = {Central pontine myelinolysis (CPM) is a rare demyelinating disorder typically linked to rapid correction of chronic hyponatremia, but can also occur in other settings of abrupt osmotic shifts. We report a case of a 62-year-old male with poorly controlled diabetes mellitus who presented with sudden onset of dysarthria, dysphagia, and gait instability. Despite being normonatremic throughout hospitalization, he exhibited severe hyperglycemia and elevated serum osmolality. Neurological examination revealed cranial nerve and cerebellar dysfunction, and MRI confirmed CPM. This case highlights hyperosmolar hyperglycemic state (HHS) as an uncommon yet important cause of CPM, emphasizing the need for careful management of fluid and glucose levels in diabetic emergencies to prevent serious neurological complications},
        keywords = {Central Pontine Myelinolysis (CPM), Diabetes Mellitus, Electrolyte Imbalance, Hyperosmolar Hyperglycemic State (HHS), Hyperglycemia, Demyelination, MRI, Neurological Complications, Osmotic Demyelination Syndrome.},
        month = {June},
        }

Cite This Article

manepalli, D. S., & Sireesha, D. E., & prasad, D. K. S. (2025). A RARE PRESENTATION OF CENTRAL PONTINE MYELINOSIS SECONDARY TO HYPEROSMOLAR HYPERGLYCEMIA. International Journal of Innovative Research in Technology (IJIRT), 12(1), 1289–1294.

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